Student Expectations
How Will I Meet This Expectation?
How Did I Meet This Expectation?
Demonstrate ability to
evaluate sources of
biology information on
the internet

-I will use sources that follow the rules
listed here.
-I will try to find peer reviewed websites.
-I used sources that follow the rules listed here.
-The sources were also peer reviewed here.
Demonstrate an ability
to read and understand
current biology news
-I will find enough credible information to
fully understand the news.
-I found credible information from
credible science news websites.
-I did not fully understand what
Gene therapy was, so I looked up
gene therapy on a credible website
and put a link to it in my post.
(see below)
Demonstrate proper
use of online resources

-I will hyperlink my sources in my post.
-I will use creative commons pictures
relating to my subject inside my posts.
-The sources in my post have
been hyperlinked (see below).
-The picture I used was creative
commons and related to my post.
Publish work that is
available for peer-review
-I will put my post on the class wiki
for peer review before submitting it.
-I have added my post
for peer review below.
-I added a link to my post
on my doink animation desciption.
-I have added a link to my post
on my twitter account.
Discuss published work
with a practicing biologist
in that particular field

-I will try to put comments on other
biology blogs owned by scientists.

Provide constructive
peer-review to
classmates
-I will help review posts and try to improve
posts made by my peers.
I edited and reviewed Erik's postand
Connor's post.
Discuss in-class
assignments

-I will try to connect a post to something
that we are working on or have worked on in class.
-My post is related to genes and is
about sickle cell disease, which we
have discussed in class.
Apply creativity
to work
-I will try to make posts as interesting as
possible
-If possible i could create a diagram to help
explain my post.
-I made my post on an interesting topic.
-I made a doink animation explaining my post here.
Gene Therapy Cure for Sickle Cell Disease?
By Chris
http://flickr.com/photos/ernestfigueras/2475413549/

Sickle-cell disease is a dangerous heritable genetic blood disorder that causes a mutation in the beta-globin gene. This gene produces hemoglobin, a protein in red blood cells that carries oxygen to tissues. When the beta globin gene is mutated, the hemoglobin sticks together and the red blood cells become sickle-shaped, causing them to block blood vessels. In most cases, this disease proves fatal.
For many years, scientists have been trying to find a way to increase the production of normal hemoglobin, but until now, have been unsuccessful. A new discovery has been made that could lead to curing this disease. Gene therapy, or adding a new gene to a cell to replace a malfunctioning gene could be applied to cure this disease. Robert Pawluik and his colleagues at the Massachusetts Institute of Technology created a non-sickle beta globin gene to replace the sickle genes. They injected the gene into the part of the mice that had the sickling gene with a harmless virus containing the new gene.
Ten months after gene therapy was applied to the mice, around 99% of the sickle cells were replaced with normal cells. Derek Persons M.D., PhD, conducted a similar experiment. He and his colleagues at the St. Jude Department of Hematology used gene therapy to give the mice and their blood-making cells the gamma-globin gene. Months after the mice were treated, the mice showed almost no signs of the disease.
While these results are promising, much time and work is still needed before this can be tried on humans.

this is cool. hope it works on humans! -erik


Are there any other gene related diseases that scientist could use gene therapy to try and cure? Do you think that this could lead to curing sickle-cell disease in humans?

Connor: I read this post and I think that the content is good. I do not see any clear errors in what you said about sickle cell anemia. The one problem is that you should add questions at the end